Role of hormonal environment, partial hepatectomy, and dose of ethylnitrosourea in renal carcinogenesis.

For evaluation of factors modifying renal carcinogenesis, several groups of 6-week-old C57BL X C3H Fj mice of both sexes were exposed once to 60 or 121)ng ot ethylnitrosourea per g of body weight. This treatment was preceded in some groups by partial hepatectomy and/or ovariectomy. Animals were killed at 90 weeks of age, and the incidence of renal tumors was evaluated. Ethylnitrosourea induced papillary cystadenomas and solid granular and clear cell-type tumors. The incidence of tumors was dependent upon the dose. Sex difference was revealed in groups exposed to higher doses of ethylnitrosourea. Only the combination of partial hepatectomy and bilateral ovariectomy significantly augmented development of kidney tumors.